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Diehn and Alizadeh also have helped to build up an assay in Stanford’s Molecular Pathology Laboratory to recognize the presence of genetic changes in a tumor that can be targeted by existing drugs or treatments. Krasnow acquired some more experts he wanted to involve still. Krasnow said. Irving Weissman, MD, director of Stanford’s Institute for Stem Cell Biology and Regenerative Medicine and of its Ludwig Center for Cancer Stem Cell Research and Medicine, suit you perfectly perfectly.
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He and Spudich are old friends. Rahul Sinha, Ph.D., a previous postdoctoral scholar in Weissman’s lab and an trainer at the institute, came on board to collect the necessary tissue and blood samples and initiate the analysis of tumor-infiltrating immune cells. Finally, Krasnow called professor of medicine Calvin Kuo, MD, Ph.D., and hematology and oncology fellow Ameen Salahudeen, MD, PHD. The two had been attempting to establish new ways to culture normal and cancerous individual lung tissue from surgical biopsies to review human-specific biology. With Tushar Desai Together, MD, assistant teacher of medicine, they had recognized the presumed cell-of-origin for lung adenocarcinoma in humans recently.
By the next morning hours, Spudich himself was “a very busy patient,” putting your signature on multiple consent forms and being briefed on what his involvement in each study entailed. Krasnow said. “In everything he will, he has an excellent mixture of vision and wish. This was no different.” Meanwhile, the speedy response team was waiting and gowned, somewhat nervously, outside an operating room at Stanford Hospital.
Kuo is at the operating room to go over with Shrager and the pathologists ways to get the best samples of normal and diseased cells for the planned analysis. Beneath the care of Shrager and his team and Heather Wakelee, MD, teacher of oncology and a specialist in lung cancers, Spudich retrieved quickly from the surgery. Because his cancer was caught early and removed fully, it’s presumed to be cured. However, the existing standard of care suggests several rounds of chemotherapy to reduce the opportunity of any possible recurrence. For patients with metastatic disease, the prognosis is less positive.